Neuroscience
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Histamine - Anatomy

Histamine cells (HA) are located exclusively in the basal posterior hypothalamus. These cells project extensively throughout the neural axis in a manner analogous to the NE and 5-HT systems. Although HA has not been investigated extensively, based on its diffuse innervation of the CNS and lack of classic synaptic contacts, it is likely that histamine has a broad behavioral and physiological function.

Histamine is also the major active substance released from mast cells. The presence of mast cells in the blood in the CNS has hindered the analysis of the role of histamine as a neurotransmitter.

Figure 12.6 Histamine neuronal pathways mapped in the rat CNS using histidine decarboxylase immunoreactivity.

Cross Reference: Links for Histamine