Table VII:
Neuropharmacological Agents that Interact with Monoamines

Drug Action Clinical Use
L DOPA Converted to DA Reduce symptoms of Parkinson’s disease
Carbidopa Converted to DA only in the CNS (contains peripheral AADC inhibitor) Reduce symptoms of Parkinson’s disease
Isoproterenol (Isuprel) Stimulate b receptors Arterial and bronchial dilation Relax smooth muscle of the bronchioles
Acebutolol (Atenolol) Blocks b receptors Anti-hypertension

Treat coronary heart disease, angina pectoris, ventricular arrhythmias, migraine and hyperthyroidism

Sumatriptan (Imitrex) Stimulate 5-HT1 receptors Treat hypertension or migraine
Tryptophan Increases 5-HT level Promotes sleep
Fenfluramine Inhibits 5-HT reuptake Hunger suppression
Imipramine (Tofranil) Inhibits both NE and 5-HT reuptake Antidepressant
Clomipramine (Anafranil) Inhibits both 5-HT and NE reuptake Antidepressant

Treat obsessive-compulsive disorder.

Desipramine (Norpramin) Inhibits NE reuptake Antidepressant
Nortriptyline (Pamelor) Inhibits NE reuptake Antidepressant
Fluoxetine (Prozac)

Sertraline (Zoloft)

Paroxetine (Paxil)

Fluvoxamine (Luvox)

Inhibit 5-HT reuptake (SSRI) Antidepressants.

Although not yet approved by the FDA, SSRIs are reported to be helpful in treating premature ejaculation, chronic pain, obsessive compulsive disorder, panic disorder, and premenstrual dysphoric disorder.

Lithium Mechanism of action in controlling mania is unknown. Mania
Bupropion (Wellbutrin) Unknown Antidepressant

Smoking cessation

Haloperidol (Haldol) D2 receptor antagonist Management of the manifestations of psychotic disorders (antipsychotic).

Treatment of tics and vocal utterances of Tourette's Disorder.

Ranitidine (Zantac) H2 receptor blocker Gastric acid secretion blocker
Olanzapine (Zyprexa) D1-4, 5-HT2A/2C, a2, M1-5 and H1 receptor antagonists Antipsychotic
Risperidone (Risperdal) DA or 5-HT antagonist Antipsychotic
Methylphenidate (Ritalin) Unknown- probably DA, NE or 5-HT reuptake blockers or releasers (similar to amphetamine) A mild CNS stimulant that presumably activates the brain stem arousal system and cortex to produce its stimulant effect.
Phenelzine, tranylcypromine, iproniazid and pargyline Irreversible MAO inhibitors Antidepressants (used in the past- now only secondary choice)
Deprenyl Reversible MAO inhibitor Treat Parkinson’s disease