The principle catecholamines are dopamine, norepinephrine and epinephrine (adrenaline).  The latter two are shown above.

CAM-KINASE II = Calcium/calmodulin- dependent protein kinase

Kinase A = cAMP-dependent protein kinase

Kinase C = Calcium/phospholipid activated protein kinase

MAP2 KINASE = Mitogen activated protein kinase

Schematic representing the phosphorylation of tyrosine hydroxylase (TOHase) by four protein kinase systems in adrenergic chromaffin cells.  Acetylcholine is responsible for the Ca+-mediated changes whle VIP or PACAP appear responsible for the Kinase A- , and possible the Kinase C-, mediated phosphorylation.  Also shown is the possibility that Ca++may also stimulate cAMP production through stimulation of Ca++ sensative adenylyl cyclase.  It is not yet known which of these mechanisms is predominately responsible for catecholamine synthesis regulation