Mechanisms of Memory Formation and Memory Dysfunction
Different brain regions, and distinct cellular and molecular mechanisms contribute to the formation, storage and recall of memory. Depending on the duration, memory processes can be classified into working memory, short-, intermediate- and long-term memory.
Our laboratory studies the cellular and molecular mechanisms that underlie each form of memory, with particular focus on the role of the prefrontal cortex and the hippocampus. In addition to our research on exploring memory mechanisms in normal brains, we are working towards understanding how traumatic brain injury (TBI) impairs memory function.
TBI causes enduring deficits in each of the aforementioned types of memory, often in the absence of overt damage to the hippocampus or prefrontal cortex. We hope to develop strategies that can be used to lessen brain damage and improve learning and memory in the injured brain.